Set against the backdrop of the city of Amsterdam, Piet Van der Valk and his team investigate a series of high-profile cases immersed in the worlds of art, politics, addiction, mysticism and the fashion industry.
Van der Valk and the team are called in when a scientist researching a potential breakthrough in the treatment of cancer is found dead. Van der Valk's ex-flame Kalie Tenkers returns to help the team investigate why he was killed and if there is a link to pharmaceutical billionaire Freddie Klink.